Protein restriction reprograms the multi-organ proteomic landscape of mouse and human aging
The phenomenon of population aging is becoming more evident. While protein restriction (PR) has shown potential in delaying aging, there is still limited understanding of the natural aging process in multiple organs and the specific effects of PR. Here, we conducted comprehensive proteomic analyses on 41 mouse tissues during male mouse aging and PR. PR mitigated age-related tissue-specific protein expression, epigenomic states, protein phosphorylation patterns. Overall, our study depicts multi-organ aging process and provides valuable insights into the geroprotective potential of PR.
