Clinically Driven Proteomic Research of Thyroid Diseases

Thyroid Diagram

Dimension II—The "Temporal" Aspect (Disease Progression and Diverse Physiological Phases)

  • Differentiation Process of Undifferentiated Tumors
  • Thyroid aging (Wang et al. Unpublished data)
  • Molecular Characteristics in Special Populations (Children/Elderly/Pregnant Women)
(Wang et al. Nature Communications. 2024)
  • Assessment of Benign and Malignant Thyroid Nodules
(Sun et al. Cell Discovery. 2022) (Cai et al. Journal of Clinical Oncology. Under review)
  • Utilizing the Presence or Absence of Lymph Node Metastasis to Assess and Determine the Surgical Margins
  • Optimal Timing for Surgery in Minimal Cancer Cases
(Sun et al. EMBO Molecular Medicine. Under review) (Cai et al. Chinese Medical Journal. Accepted)
  • Diagnosis of Follicular Thyroid Carcinoma and FA
  • Molecular Typing of Undifferentiated Carcinoma
  • Diagnostic Biomarkers for Distinct Pathological Subtypes
(Shi X, et al. Cell Discovery. 2022) (Li L, et al. Unpublished data)
(Sun Y, et al. Mol Oncol. 2022) (Li et al. Scientific Data. 2024)
  • Iodine-131 Radiosensitivity Assessment
  • Drug Targets Discovery for Refractory Cancer
  • Recurrence Risk Prediction
  • Risk stratification
(Li et al. Int J Surg. 2024) (Zhou Y, et al. Unpublished data)

Dimension I: The "Spatial" Aspects of Macro and Micro Scales

  • Spatial and Single-Cell Proteomics Analysis of Tumor Immune Heterogeneity and Therapy
  • Molecular Expression Variations of Tumors Among Different Geographical Ethnicities/Races